African American Study of Kidney Disease & Hypertension (AASK)

Study characteristics: 1094 African Americans with reduced creatinine clearance & hypertension Groups: - 2 blood pressure* goals: a) 102-107 mm Hg b) 92 mm Hg * mean arterial pressure 3 antihypertensive agents - metoprolol, ramipril, or amlodipine Results: 1) risk of developing diabetes significantly lower with ramipril than with metoprolol or amolodipine (RR=0.53) 2) group with lower blood pressure goal more likely to develop diabetes

References

Thornley-Brown D, Wang X, Wright JT Jr, Randall OS, Miller ER, Lash JP, Gassman J, Contreras G, Appel LJ, Agodoa LY, Cheek D. Differing effects of antihypertensive drugs on the incidence of diabetes mellitus among patients with hypertensive kidney disease. Arch Intern Med. 2006 Apr 10;166(7):797-805. PMID: 16606818