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Aflatoxin B1 aldehyde reductase member 4 (AKR7A4, AFAR3, AKR7L)
Function:
- can reduce dialdehyde protein-binding form of aflatoxin B1 to the non-binding aflatoxin B1 dialcohol
- may be involved in protection of liver against the toxic & carcinogenic effects of aflatoxin B1 (putative)
Structure: belongs to the aldo/keto reductase 2 family
Expression: Mainly expressed in uterus
General
aldo-keto reductase
Properties
SIZE: MW = 37 kD
entity length = 331 aa
MOTIF: tyrosine residue {Y49}
Lowers pKa of active site Tyr {77-77}
selenocysteine residue {C106}
binding site
SITE: 113-113
FOR-BINDING-OF: Substrate
cofactor-binding site [198-208]
COFACTOR-BOUND: NADP
Database Correlations
UniProt Q8NHP1
Pfam PF00248
References
UniProt :accession Q8NHP1