Search
aldo-keto reductase family 7, member A3; aflatoxin B1 aldehyde reductase 2; AFB1-AR 2 (AKR7A3, AFAR2)
Function:
- can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol
- may be involved in protection of liver against the toxic & carcinogenic effects of AFB1, a potent hepatocarcinogen (putative)
Structure:
- probably act as a homodimer (putative)
- belongs to the aldo/keto reductase 2 family
Compartment: cytoplasm
Expression:
- expressed in colon, kidney, pancreas, adenocarcinoma & endometrium
General
aldo-keto reductase
Properties
SIZE: entity length = 331 aa
MW = 37 kD
COMPARTMENT: cytoplasm
MOTIF: tyrosine residue {Y49}
lysine residue {77}
binding site
SITE: 113-113
FOR-BINDING-OF: Substrate
cofactor-binding site [198-208]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 608477
UniProt O95154
Pfam PF00248
Entrez Gene 22977
Kegg hsa:2297
References
UniProt :accession O95154