aldo-keto reductase family 7, member A2; aflatoxin B1 aldehyde reductase 2 (AKR7A2, AFAR, AFAR1, AKR7)

phase 2 drug metabolizing enzyme Function: - phase 2 drug metabolizing enzyme - can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol - may be involved in protection of liver against the toxic & carcinogenic effects of AFB1, a potent hepatocarcinogen (putative) - probably act as a homodimer (putative) Structure: belongs to the aldo/keto reductase 2 family Compartment: Golgi apparatus (putative) Expression: widely expressed Note: uncertain whether Met-1 or Met-30 is the initiator

General

aldo-keto reductase phosphoprotein

Properties

SIZE: entity length = 359 aa MW = 40 kD COMPARTMENT: golgi MOTIF: Ser phosphorylation site {S40} tyrosine residue {Y77} histidine residue {H112} cofactor-binding site [226-236] COFACTOR-BOUND: NADP

Database Correlations

OMIM 603418 UniProt O43488 Pfam PF00248 Entrez Gene 8574 Kegg hsa:8574

References

UniProt :accession O43488