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fibroblast growth factor 1; FGF-1; acidic fibroblast growth factor; aFGF; endothelial cell growth factor; ECGF; heparin-binding growth factor 1; HBGF-1 (FGF1, FGFA)

Function: - cell injury may liberate FGF-1 - FGF-1 forms homodimer via C30 disulfide in aerobic environment [5] - homodimer weakly binds heparin & is inactive - role in the regulation of cell survival, cell division, angiogenesis, cell differentiation & cell migration - potent mitogen in vitro - interacts with FGFR1, FGFR2, FGFR3 & FGFR4 - affinity between fibroblast growth factors (FGFs) & their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors - found in a complex with FGFBP1, FGF1 & FGF2 - interacts with FGFBP1 - part of a Cu+2-dependent multiprotein aggregate containing FGF1, S100A13 & SYT1 - interacts with SYT1 (putative) - interacts with S100A13 Structure: - monomer, homodimer - belongs to the heparin-binding growth factors family - precursor does not contain ER signal sequence Compartment: - secreted - within the cytoplasm, it is transported to the cell membrane & then secreted by a non- classical pathway that requires Cu+2 & S100A13 - secreted in a complex with SYT1 (putative) Alternative splicing: named isoforms=2 Comparative biology: - injection of FGF-1 into the cerebral ventricles of mice or rats with type 2 diabetes conferred glucose control for at least 17 weeks

General

fibroblast growth factor secreted peptide without leader

Properties

SIZE: entity length = 155 aa MW = 17 kD COMPARTMENT: cytoplasm MOTIF: binding site SITE: 33-33 FOR-BINDING-OF: heparin binding site SITE: 127-143 FOR-BINDING-OF: heparin SECRETED-BY: macrophage platelet endothelial cell

Database Correlations

OMIM 131220 UniProt P05230 Pfam PF00167 Entrez Gene 2246 Kegg hsa:2246

References

  1. Machida CM et al NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 1989 Jun;2(6):1587-96 PMID: 2560648
  2. Imamura T et al Recovery of mitogenic activity of a growth factor mutant with a nuclear translocation sequence. Science 249:1567 1990 PMID: 1699274
  3. OMIM :accession 131220
  4. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  5. T. Maciag, Holland Laboratory, American Red Cross, Rockville, MD
  6. Entrez Gene :accession 2246
  7. UniProt :accession P05230
  8. NIEHS-SNPs http://egp.gs.washington.edu/data/fgf1/
  9. Scarlett JM et al. Central injection of fibroblast growth factor 1 induces sustained remission of diabetic hyperglycemia in rodents. Nat Med 2016 Jul; 22:800. PMID: 27213816