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band 3-related protein; anion exchange protein 2; anion exchanger 2; AE 2; non-erythroid band 3-like protein; BND3L; solute carrier family 4 member 2 (SLC4A2, AE2 ,EPB3L1, HKB3, MPB3L)
Function:
- plasma membrane anion exchange protein
- Cl-/HCO3- exchange.
Structure: belongs to the anion exchanger (TC 2.A.31) family
Compartment: membrane
Alternative splicing: named isoforms=2; Additional isoforms seem to exist
Expression: wide distribution
General
anion exchange protein
Cl- channel
solute carrier family 4 (SLC4, SLC4A)
Properties
SIZE: entity length = 1241 aa
MW = 137 kD
COMPARTMENT: plasma membrane
MOTIF: cytoplasmic domain {1-707}
MOTIF: proline-rich region
SITE: 5-320
MOTIF: proline residue (SEVERAL)
Tyr phosphorylation site {Y73}
Ser phosphorylation site {S113}
Ser phosphorylation site {S132}
Ser phosphorylation site {S170}
Ser phosphorylation site {S172}
Ser phosphorylation site {S173}
Thr phosphorylation site {T183}
transmembrane domain {708-731}
exoplasmic loop {732-736}
transmembrane domain {737-774}
cytoplasmic loop {775-783}
transmembrane domain {784-816}
exoplasmic loop {817-825}
transmembrane domain {826-847}
exoplasmic loop {848-900}
MOTIF: N-glycosylation site {N859}
N-glycosylation site {N868}
N-glycosylation site {N882}
transmembrane domain {901-918}
cytoplasmic loop {919-933}
transmembrane domain {934-954}
exoplasmic loop {955-987}
transmembrane domain {988-1010}
cytoplasmic loop {1011-1035}
transmembrane domain {1036-1059}
exoplasmic loop {1060-1090}
transmembrane domain {1091-1136}
cytoplasmic loop {1137-1162}
transmembrane domain {1163-1199}
MOTIF: cysteine residue {C1173}
MODIFICATION: palmitate
COMPARTMENT: membrane
cytoplasmic domain {1200-1241}
ION-PERMEABILITY: Cl-
Database Correlations
OMIM 109280
UniProt P04920
PFAM correlations
Entrez Gene 6522
Kegg hsa:6522
References
- Alperts et al Molecular Biology of the Cell, Garland
Publishing, New York, NY 1989 pg 289-291
- Wang KK et al
Calmodulin-binding proteins as calpain substrates.
Biochem J 262:693 1989
PMID: 2556106
- UniProt :accession P04920
- NIEHS-SNPs
http://egp.gs.washington.edu/data/slc4a2/