adult granulosa cell tumor

Epidemiology: - account for ~1-5% of all ovarian tumors - account for ~95% of granulosa cell tumors - occur more often in post-menopausal women - peak incidence ~50-55 yrs. - most common estrogenic ovarian tumor Microscopic Pathology: - variable microscopic patterns: - microfollicular - contain small cavities simulating Call-Exner bodies of developing graafian follicle - macrofollicular - insular - trabecular - solid-tubular - hollow-tubular - moire silk or diffuse pattern associated with poorer differentiation - nuclei relatively uniform, pale, some with nuclear groove - variable amounts of theca cells - mitoses variable, usually not pronounced Genetics: - may be associated with 402C->G point mutation in the FOXL2 gene

References

- Shah SP et al Mutation of FOXL2 in granulosa-cell tumors of the ovary. N Engl J Med 2009 Jun 25; 360:2719. PMID: 19516027 - Shendure J and Stewart CJ. Cancer genomes on a shoestring budget. N Engl J Med 2009 Jun 25; 360:2781. PMID: 19516026