beta adrenergic receptor kinase-1 (ADRBK1, G protein-coupled receptor kinase-2)

Function: - specifically phosphorylates agonist-occupied form of the beta-adrenergic receptors & closely related receptors, probably inducing a desensitization of them - interacts with GIT1 (putative) - interacts with, & phosphorylates chemokine-stimulated CCR5 ATP + [beta-adrenergic receptor] ADP + [beta-adrenergic receptor] phosphate Structure: - belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family, GPRK subfamily - contains 1 AGC-kinase C-terminal domain - contains 1 PH domain - contains 1 protein kinase domain - contains 1 RGS domain Expression: expressed in peripheral blood leukocytes

Properties

SIZE: entity length = 689 aa MW = 80 kD STATE: active state MOTIF: N-terminal {1-190} MOTIF: RGS {54-175} kinase domain SITE: 191-453 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 197-205 ATP-binding site NAME: ATP-binding site SITE: 220-220 aspartate residue {D317} AGC-kinase C-terminal {454-521} PH domain {558-652} MISC-INFO: RECOGNITION-MOTIF :SEQUENCE GY[S*][S*]NGN[T*]GEQ[S*]G[X16]G[T*]ED[X5]G[T*]VP[S*]DNID[S*]Q[X3][S*][T*]ND[S*]LL :REF " - Kemp BE, Pearson RB. Protein kinase recognition sequence motifs. Trends Biochem Sci. 1990 Sep;15(9):342-6. Review. PMID: 2238044"

Database Correlations

OMIM 109635 UniProt P25098 PFAM correlations Entrez Gene 156 Kegg hsa:156 ENZYME 2.7.11.15