Search
beta-3 adrenergic receptor; beta-3 adrenoreceptor; beta-3 adrenoceptor (ADRB3, ADRB3R, B3AR)
Function:
- beta-adrenergic receptor
- role in regulation of lipolysis & thermogenesis
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed mainly in adipose tissues
- expressed in brown adipose tissue
Polymorphism:
- variant Arg-64 seems to be associated with weight gain (obesity) & to is also associated with susceptibility to non-insulin-dependent diabetes mellitus (NIDDM)
General
beta adrenergic receptor
Properties
SIZE: entity length = 408 aa
MW = 44 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-36}
MOTIF: N-glycosylation site {N8}
N-glycosylation site {N26}
transmembrane domain {37-63}
cytoplasmic loop {64-72}
transmembrane domain {73-91}
exoplasmic loop {92-111}
MOTIF: cysteine residue {C110}
MODIFICATION: cysteine residue {C189}
transmembrane domain {112-133}
cytoplasmic loop {134-155}
transmembrane domain {156-178}
exoplasmic loop {179-203}
MOTIF: cysteine residue {C189}
MODIFICATION: cysteine residue {C110}
transmembrane domain {204-225}
cytoplasmic loop {226-292}
transmembrane domain {293-314}
exoplasmic loop {315-326}
transmembrane domain {327-347}
cytoplasmic domain {348-408}
MOTIF: cysteine residue {C361}
MODIFICATION: palmitate
COMPARTMENT: membrane
Database Correlations
OMIM 109691
MORBIDMAP 109691
UniProt P13945
Pfam PF00001
Entrez Gene 155
Kegg hsa:155
References
- UniProt :accession P13945
- SeattleSNPs
http://pga.gs.washington.edu/data/adrb3/
- Emorine L, Blin N, Strosberg AD.
The human beta 3-adrenoceptor: the search for a physiological
function.
Trends Pharmacol Sci. 1994 Jan;15(1):3-7. Review.
PMID: 8140656