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beta-2 adrenergic receptor; beta-2 adrenoreceptor; beta-2 adrenoceptor (ADRB2, ADRB2R, B2AR)
Function:
- beta-adrenergic receptor
- binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine
- binds SLC9A3R1 & GPRASP1
- palmitoylated; may reduce accessibility of Ser-345 & Ser- 346 by anchoring Cys-341 to the plasma membrane
- agonist stimulation promotes depalmitoylation & further allows Ser-345 & Ser-346 phosphorylation
- phosphorylated by PKA & BARK upon agonist stimulation, which mediates homologous desensitization of the receptor
- PKA-mediated phosphorylation seems to facilitate phosphorylation by BARK
- phosphorylated upon DNA damage, probably by ATM or ATR
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane; multi-pass membrane protein
Pathology:
- polymorphic forms of ADRB2 could impart some form of nocturnal asthma
- polymorphisms (C & G) alleles associated with different mortality when treated with beta-blocker after acute coronary syndrome
Interactions
molecular events
Related
inhaled beta-2 adrenergic receptor agonist
General
beta adrenergic receptor
Properties
SIZE: entity length = 413 aa
MW = 47 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-34}
MOTIF: N-glycosylation site {N6}
N-glycosylation site {N15}
transmembrane domain {35-58}
cytoplasmic loop {59-71}
transmembrane domain {72-95}
exoplasmic loop {96-106}
MOTIF: cysteine residue {C106}
MODIFICATION: cysteine residue {C184}
transmembrane domain {107-129}
MOTIF: aspartate residue {113}
cytoplasmic loop {130-150}
transmembrane domain {151-174}
exoplasmic loop {175-196}
MOTIF: cysteine residue {C184}
MODIFICATION: cysteine residue {C106}
transmembrane domain {197-220}
MOTIF: serine residue {204}
serine residue {207}
cytoplasmic loop {221-274}
MOTIF: Ser phosphorylation site {S246}
Ser phosphorylation site {S261}
Ser phosphorylation site {S262}
transmembrane domain {275-298}
exoplasmic loop {299-305}
transmembrane domain {306-329}
cytoplasmic domain {330-413}
MOTIF: cysteine residue {C341}
MODIFICATION: palmitate
COMPARTMENT: membrane
Ser phosphorylation site {S345}
Ser phosphorylation site {S346}
Ser phosphorylation site {S355}
Ser phosphorylation site {S356}
Database Correlations
OMIM 109690
MORBIDMAP 109690
UniProt P07550
Pfam PF00001
Entrez Gene 154
Kegg hsa:154
References
- Molecular Cell Biology (2nd ed) Darnell J; Lodish H
& Baltimore D (eds), Scientific American Books,
WH Freeman, NY 1990, pg 748
- Principles of Neural Science, 3rd ed. Kandel ER,
Schwartz JH & Jessell TM (eds), Elsevier NY 1991,
pg 175
- Lanfear DE, Jones PG, Marsh S, Cresci S, McLeod HL, Spertus JA.
Beta2-adrenergic receptor genotype and survival among patients
receiving beta-blocker therapy after an acute coronary syndrome.
JAMA. 2005 Sep 28;294(12):1526-33.
PMID: 16189366
- UniProt :accession P07550
- GeneReviews
https://www.genecards.org/cgi-bin/carddisp.pl?gene=ADRB2
- SeattleSNPs
http://pga.gs.washington.edu/data/adrb2/