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ADP-ribose pyrophosphatase, mitochondrial; ADP-ribose diphosphatase; ADP-ribose phosphohydrolase; adenosine diphosphoribose pyrophosphatase; ADPR-PPase; nucleoside diphosphate-linked moiety X motif 9; Nudix motif 9 (NUDT9, PSEC0099, UNQ3012/PRO9771)
Function:
- hydrolyzes ADP-ribose (ADPR) to AMP & ribose 5'-phosphate
- interacts with C17orf25
ADP-ribose + H2O = AMP + D-ribose-5-phosphate
Cofactor: Mg+2, Mn+2
Inhibition:
- isoform 1 is inhibited by fluoride & N-acetyl-p-benzoquinoneimine
Structure:
- monomer
- belongs to the Nudix hydrolase family, NudF subfamily
- contains 1 nudix hydrolase domain
Compartment: isoform 1: mitochondrion
Alternative splicing: named isoforms=2
Expression:
- ubiquitously expressed
- isoform 1 is the most predominant isoform
Related
ADP ribose
General
phosphoprotein
pyrophosphatase (diphosphohydrolase)
Properties
SIZE: entity length = 350 aa
MW = 39 kD
COMPARTMENT: mitochondria
MOTIF: Ser phosphorylation site {S68}
Ser phosphorylation site {S121}
Nudix hydrolase {178-334}
MOTIF: Nudix box {215-237}
Database Correlations
OMIM 606022
UniProt Q9BW91
Pfam PF00293
Entrez Gene 53343
Kegg hsa:53343
ENZYME 3.6.1.13
References
UniProt :accession Q9BW91