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adenosine diphosphate [ADP] receptor
Interactions
molecular events
Related
adenosine 5'-diphosphate (ADP)
Specific
P2Y12 purinoceptor; P2Y purinoceptor 12; P2Y12; P2Y12 platelet ADP receptor; P2Y(ADP); ADP-glucose receptor; ADP receptor P2Y12; ADPG-R; P2Y(AC); P2Y(cyc); P2T(AC); SP1999 (P2RY12, HORK3)
General
G-protein coupled receptor; serpentine receptor
Properties
COMPARTMENT: plasma membrane
CELL: monocyte
MOTIF: exoplasmic domain {N-TERMINAL}
ligand-binding site
transmembrane domain {TM1}
transmembrane domain {TM2}
transmembrane domain {TM3}
transmembrane domain {TM4}
transmembrane domain {TM5}
transmembrane domain {TM6}
transmembrane domain {TM7}
transmembrane domain (7)
guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
binding site
SITE: C-TERMINAL-CYS
EFFECTOR-BOUND: palmitate
BOUND-VIA: carboxylate
cytoplasmic domain {C-TERMINAL}
References
- Altieri DC, Wiltse WL, Edgington TS.
Signal transduction initiated by extracellular nucleotides
regulates the high affinity ligand recognition of the adhesive
receptor CD11b/CD18.
J Immunol. 1990 Jul 15;145(2):662-70.
PMID: 1973186