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adoptive cell transfer
Indications:
- treatment of melanoma [1]
Procedure:
- CD8+ & CD4+ T cells are extracted from a patient's tumor tissue & cultured to large numbers
- CD8+ & CD4+ T cells are then stimulated to attack tumor cells more aggressively, & reinfused into the patient
- often, a patient's lymphocyte population is depleted by chemotherapy prior to reintroduction of the amplified & stimulated CD8+ & CD4+ T cells
- in the absence of other lymphocytes, the reintrocdued CD8+ & CD4+ T cells proliferate rapidly [1]
General
cancer immunotherapy
References
- Komaroff AL
Immunotherapy to Fight Cancer Begins to Work.
NEJM Journal Watch. June 16, 2015
Massachusetts Medical Society
(subscription needed) http://www.jwatch.org
- Rosenberg SA and Restifo NP.
Adoptive cell transfer as personalized immunotherapy for
human cancer.
Science 2015 Apr 3; 348:62
PMID: 25838374
- June CH et al.
Adoptive cellular therapy: A race to the finish line.
Sci Transl Med 2015 Mar 25; 7:280ps7.
PMID: 25810311