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adenylyl cyclase-associated protein 1; CAP-1 (CAP1, CAP)
Function:
- directly regulates filament dynamics
- implicated in a number of complex developmental & morphological processes, including mRNA localization & the establishment of cell polarity
- binds actin monomers
Structure:
- homodimer
- belongs to the CAP family
- contains 1 C-CAP/cofactor C-like domain
Compartment: cell membrane; peripheral membrane protein
Alternative splicing: named isoforms=2
General
membrane protein
phosphoprotein
Properties
SIZE: entity length = 475 aa
MW = 52 kD
COMPARTMENT: cellular membrane
MOTIF: acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y164}
serine-rich region {218-256}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 230-241
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S290}
Ser phosphorylation site {S295}
Ser phosphorylation site {S301}
Thr phosphorylation site {T307}
Ser phosphorylation site {S308}
Ser phosphorylation site {S310}
C-CAP/cofactor C-like {319-453}
Database Correlations
UniProt Q01518
PFAM correlations
Entrez Gene 10487
Kegg hsa:10487
References
UniProt :accession Q01518