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adenylate kinase-1 (AK1, ATP/AMP phosphotransferase, myokinase)
Function:
- small ubiquitous enzyme essential for maintenance & cell growth
ATP + AMP 2 ADP
Structure:
- monomer
- belongs to the adenylate kinase family
Compartment:
- cytoplasm
Polymorphism:
- most common of at least 5 alleles
Pathology:
- defects in AK1 are associated with hemolytic anemia
Related
glycogen storage disease type-VIII
General
adenylate kinase or adenyl kinase
Properties
SIZE: entity length = 194 aa
MW = 22 kD
COMPARTMENT: cytoplasm
MOTIF: acetylation site
SITE: 1-1
EFFECTOR-BOUND: acetyl
ATP-binding site
NAME: ATP-binding site
SITE: 15-23
histidine residue {H36}
aspartate residue {D93}
Database Correlations
OMIM 103000
MORBIDMAP 103000
UniProt P00568
Pfam PF00406
Entrez Gene 203
KEGG correlations
ENZYME 2.7.4.3
References
- OMIM :accession 103000
- Wikipedia; Note: adenylate kinase entry
http://en.wikipedia.org/wiki/adenylate_kinase