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adenocarcinoma
A malignant neoplasm of epithelial cells in a glandular pattern.
Laboratory:
1) complete blood count may show anemia & thrombocytopenia
2) peripheral smear may show erythrocyte fragments
Genetics:
- upregulation of C16orf34
Complications:
- hemolytic anemia secondary to intravascular trauma may occur
Management:
- prophylaxis
- aspirin may reduce mortality from several adenocarcinomas
- apparent benefit increases with duration of treatment
- benefit becomes apparent after 5 years of treatment
- not related to daily dose
- benefit confined to adenocarcinomas [3]
Interactions
disease interactions
Related
adenoma
Specific
adenocarcinoma of the colon &/or rectum
adenocarcinoma of the lung
ampulla of Vater adenocarcinoma
cholangiocarcinoma
cystadenocarcinoma
ductal adenocarcinoma
follicular thyroid carcinoma
hepatocellular carcinoma
Krukenberg's tumor
lobular carcinoma, breast
metastatic adenocarcinoma of unknown primary
mucinous adenocarcinoma (colloid cancer)
pancreatic adenocarcinoma
papillary adenocarcinoma
prostate adenocarcinoma
renal cell carcinoma (hypernephroma, Grawitz tumor)
sebaceous adenocarcinoma
small intestinal adenocarcinoma
General
carcinoma
glandular epithelial neoplasm
References
- Stedman's Medical Dictionary 27th ed, Williams &
Wilkins, Baltimore, 1999
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 668
- Rothwell PM et al
Effect of daily aspirin on long-term risk of death due to
cancer: analysis of individual patient data from randomised
trials
Lancet. 2011 Jan 1;377(9759):31-41. Epub 2010 Dec 6.
PMID: 21144578
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)62110-1/abstract