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adefovir (Hepsera)

Indications: 1) hepatitis B (long-term) a) may be combined with interferon-alpha 2b or lamivudine b) response not sustained with 48 weeks of treatment [2] 2) nephrotoxic at doses needed to treat patients with AIDS Dosage: - need to take with L-carnitine Storage: - keep in original container - original container has a desiccant [3] Adverse effects: nephrotoxic Laboratory: - adefovir in serum/plasma

Interactions

drug interactions drug adverse effects of antiretroviral agents

Related

Acquired Immuno-Deficiency Syndrome (HIV infection stage 3, AIDS)

General

nucleoside reverse transcriptase inhibitor (NRTI)

Database Correlations

PUBCHEM correlations

References

  1. Prescriber's Letter 9(10):55 2002
  2. Journal Watch 25(16):130, 2005 Hadziyannis SJ, Tassopoulos NC, Heathcote EJ, Chang TT, Kitis G, Rizzetto M, Marcellin P, Lim SG, Goodman Z, Ma J, Arterburn S, Xiong S, Currie G, Brosgart CL; Adefovir Dipivoxil 438 Study Group. Long-term therapy with adefovir dipivoxil for HBeAg- negative chronic hepatitis B. N Engl J Med. 2005 Jun 30;352(26):2673-81. PMID: 15987916
  3. Prescriber's Letter 21(6): 2014 Oral Meds to Keep in Original Containers Detail-Document#: 300622 (subscription needed) http://www.prescribersletter.com