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adaptin ear-binding coat-associated protein 2 (NECAP-2, NECAP2)
Function:
- role in endocytosis (putative)
- interacts with AP1G1 & AP2A1 components of the adapter protein complexes AP-1 & AP-2
- interacts with the GAE domain proteins GGA1, GGA2 & GGA3 (putative)
Structure:
- belongs to the NECAP family
- WXXF motifs mediate binding of accessory proteins to the ear-domain of AP-1, GGAs & AP-2 through hydrophobic interactions. Selective binding to the GAE domains of AP-1 or to the alpha-ear domain of AP-2 is tuned by the acidic context surrounding the motif & the properties of the 2nd residue of the motif itself (putative)
Compartment:
- cytoplasmic vesicle
- clathrin-coated vesicle membrane (putative)
- cell membrane
- colocalizes with AP-2 at the plasma membrane (putative)
Alternative splicing: named isoforms=3
General
other protein
Properties
SIZE: MW = 28 kD
entity length = 263 aa
COMPARTMENT: cytoplasm
MOTIF: WXXF motif 1 {240-243}
WXXF motif 2 {260-263}
Database Correlations
UniProt Q9NVZ3
Pfam PF07933
References
UniProt :accession Q9NVZ3