ADan amyloid

Derived from integral membrane protein 2B (ITM2B). Pathology: - 10 nucleotide duplication in ITM2B gene between aa 265 & 266 just before stop codon results in a 277 aa residue protein (normal 266 aa), of which release of the 34 C-terminal amino acids generates amyloid - this mutation is associated with familial Danish dementia - deposits of ADan result in cerebral amyloid angiopathy

Properties

SIZE: entity length = 34 aa