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CD156; cell surface antigen MS2; a disintegrin & metalloproteinase domain 8 (ADAM8)
Function: role in extravasation of leukocytes (putative)
Cofactor: binds 1 Zn+2 per subunit (probable)
Structure:
- contains 1 disintegrin domain
- contains 1 EGF-like domain
- contains 1 peptidase M12B domain
Compartment: plasma membrane
Expression: expressed on neutrophils & monocytes
General
ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
Properties
SIZE: entity length = 824 aa
MW = 89 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-16}
N-glycosylation site {N67}
N-glycosylation site {N91}
Peptidase M12B {200-400}
MOTIF: cysteine residue {C310}
MODIFICATION: cysteine residue {C395}
Zn+2-binding site
SITE: 334-334
glutamate residue {E335}
Zn+2-binding site
SITE: 338-338
Zn+2-binding site
SITE: 344-344
cysteine residue {C351}
MODIFICATION: cysteine residue {C379}
cysteine residue {C353}
MODIFICATION: cysteine residue {C362}
cysteine residue {C362}
MODIFICATION: cysteine residue {C353}
cysteine residue {C379}
MODIFICATION: cysteine residue {C351}
cysteine residue {C395}
MODIFICATION: cysteine residue {C310}
disintegrin domain {408-494}
MOTIF: N-glycosylation site {N436}
cysteine residue {C466}
MODIFICATION: cysteine residue {C486}
cysteine residue {C486}
MODIFICATION: cysteine residue {C466}
N-glycosylation site {N612}
cysteine residue {C613}
MODIFICATION: cysteine residue {C623}
cysteine residue {C617}
MODIFICATION: cysteine residue {C629}
cysteine residue {C623}
MODIFICATION: cysteine residue {C613}
cysteine residue {C629}
MODIFICATION: cysteine residue {C617}
cysteine residue {C631}
MODIFICATION: cysteine residue {C640}
cysteine residue {C640}
MODIFICATION: cysteine residue {C631}
transmembrane domain {656-676}
Database Correlations
OMIM 602267
UniProt P78325
PFAM correlations
Entrez Gene 101
Kegg hsa:101
References
UniProt :accession P78325