A disintegrin & metalloproteinase domain 11; metalloproteinase-like, disintegrin-like, & cysteine-rich protein (ADAM11, MDC)

Function: - probable ligand for integrin in the brain - non catalytic metalloprotease-like protein - precursor is cleaved by a furin endopeptidase Structure: - conserved motif [AVN[ED]CD] within the disintegrin-like domain could be involved in the binding to the integrin receptor - contains 1 disintegrin domain - contains 1 EGF-like domain - contains 1 peptidase M12B domain Compartment: membrane Alternative splicing: named isoforms=2 - long (MDC-769) - short (MDC-524) Expression: - expressed predominantly in brain - slightly detected or not at all in other tissues Pathology: - rearrangements occur in breast cancer & ovarian cancer which involve multiple exons & disrupt the coding region Note: - may be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay

Properties

MOTIF: N-glycosylation site {N96} N-glycosylation site {N163} metalloprotease domain {226-438} MOTIF: cysteine residue {C349} MODIFICATION: cysteine residue {C433} cysteine residue {C433} MODIFICATION: cysteine residue {C349} disintegrin domain {444-531} MOTIF: cysteine residue {C503} MODIFICATION: cysteine residue {C516} cysteine residue {C516} MODIFICATION: cysteine residue {C503} cysteine-rich region {532-676} MOTIF: N-glycosylation site {N605} N-glycosylation site {N673} EGF domain {677-709} MOTIF: cysteine residue {C677} MODIFICATION: cysteine residue {C692} cysteine residue {C686} MODIFICATION: cysteine residue {C698} cysteine residue {C692} MODIFICATION: cysteine residue {C677} cysteine residue {C698} MODIFICATION: cysteine residue {C686} cysteine residue {C700} MODIFICATION: cysteine residue {C709} cysteine residue {C709} MODIFICATION: cysteine residue {C700} transmembrane domain {735-755}

Database Correlations

OMIM 155120 UniProt O75078 PFAM correlations Entrez Gene 4185 Kegg hsa:4185

References

UniProt :accession O75078