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ADAM (A disintegrin & metalloproteinase domain); MDC (metalloproteinase, disintegrin, cysteine-rich) protein

Family of cell surface proteins with both potential adhesion domain & protease domain. Function: - cell adhesion - sperm-egg fusion (ADAM1 & ADAM2) - myoblast fusion (ADAM12) - ectodomain shedding of cell surface proteins (ADAM9, ADAM10, ADAM17) - activation of Notch (ADAM17) - alpha-secretase activity in Alzheimer's disease (ADAM10, ADAM17) - axon guidance Structure: - family of cell surface proteins with both potential adhesion domain & protease domain - cysteine rich region & EGF domain thought to mediate cell fusion or interaction with other proteins such as chaperone proteins - ~1/2 of ADAM proteins have metalloproteinase domain that contains a catalytic consensus sequence Compartment: plasma membrane Expression: - ADAM9, ADAM10, ADAM12, ADAM15, ADAM17 & ADAM19 show widespread expression - ADAM8 & ADAM28 are predominantly hematopoietic. - 17 ADAMs are found in CNS. - ADAM22 & ADAM23 are predominantly found in brain - IL1 induces transcription of some ADAMs

Related

A disintegrin & metalloproteinase with thrombospondin type 1 motif (ADAMTS)

Specific

A disintegrin & metalloproteinase domain 1 (ADAM1, ADAMDEC1) A disintegrin & metalloproteinase domain 2; fertilin beta; PH-30; PH30; PH30-beta; cancer/testis antigen 15; CT15 (ADAM2 FTNB) A disintegrin & metalloproteinase domain 3A; cyritestin 1 (ADAM3A) A disintegrin & metalloproteinase domain 3B; cyritestin 2 (ADAM3B) A disintegrin & metalloproteinase domain 4 (ADAM4) A disintegrin & metalloproteinase domain 5 (ADAM5) A disintegrin & metalloproteinase domain 6 (ADAM6) A disintegrin & metalloproteinase domain 8 (ADAM8), CD156 or cell surface antigen MS2 A disintegrin & metalloproteinase domain 9; metalloprotease/disintegrin/cysteine-rich protein 9; myeloma cell metalloproteinase; meltrin gamma (ADAM9, KIAA0021, MCMP, MDC9, MLTNG) A disintegrin & metalloproteinase domain 10; Kuzbanian protein homolog; mammalian disintegrin-metalloprotease; CDw156; CD156c (ADAM10, KUZ, MADM) A disintegrin & metalloproteinase domain 11; metalloproteinase-like, disintegrin-like, & cysteine-rich protein (ADAM11, MDC) A disintegrin & metalloproteinase domain 12; meltrin alpha (ADAM12, MLTN, UNQ346/PRO545) A disintegrin & metalloproteinase domain 13 (ADAM13) A disintegrin & metalloproteinase domain 14 (ADAM14) A disintegrin & metalloproteinase domain 15; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 15; MDC-15; metalloprotease RGD disintegrin protein; metargidin (ADAM15, MDC15) A disintegrin & metalloproteinase domain 16 (ADAM16) A disintegrin & metalloproteinase domain 17 (ADAM17), tumor necrosis factor alpha converting enzyme (TACE) or CD156b A disintegrin & metalloproteinase domain 18; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein III; tMDC III (ADAM18, TMDC3, UNQ858/PRO1867) A disintegrin & metalloproteinase domain 19; meltrin-beta; metalloprotease & disintegrin dendritic antigen marker; MADDAM (ADAM19, MLTNB, FKSG34) A disintegrin & metalloproteinase domain 20 (ADAM20) A disintegrin & metalloproteinase domain 21 (ADAM21) A disintegrin & metalloproteinase domain 22; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 2; metalloproteinase-disintegrin ADAM22-3 (ADAM22, MDC2) A disintegrin & metalloproteinase domain 23; metalloproteinase-like, disintegrin-like, & cysteine-rich protein 3; MDC-3 (ADAM23, MDC3) A disintegrin & metalloproteinase domain 24 (ADAM24) A disintegrin & metalloproteinase domain 25 (ADAM25) A disintegrin & metalloproteinase domain 26 (ADAM26) A disintegrin & metalloproteinase domain 28; metalloproteinase-like, disintegrin-like, & cysteine-rich protein-L; MDC-L; eMDC II (ADAM28, ADAM23, MDCL) A disintegrin & metalloproteinase domain 29; cancer/testis antigen 73; CT73 (ADAM29) A disintegrin & metalloproteinase domain 30 (ADAM30) A disintegrin & metalloproteinase domain 32 (ADAM32) A disintegrin & metalloproteinase domain 33 (ADAM33) A disintegrin & metalloproteinase domain-containing protein 7; ADAM 7; sperm maturation-related glycoprotein GP-83 (ADAM7, GP83) disintegrin & metalloproteinase domain-containing protein 5; transmembrane metalloproteinase-like, disintegrin-like, & cysteine-rich protein II; tMDC II (ADAM5P, TMDC2)

General

zinc metalloprotease

Properties

MOTIF: metalloprotease domain MOTIF: active site MOTIF: Zn+2-binding site EFFECTOR-BOUND: Zn+2 MOTIF: histidine residue (2) glutamate residue disintegrin domain cysteine-rich region EGF domain membrane region

References

  1. Yong VW et al Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat Rev Neurosci. 2005 Dec;6(12):931-44. Review. PMID: 16288297
  2. Yong VW et al Metalloproteinases in biology and pathology of the nervous system. Nat Rev Neurosci. 2001 Jul;2(7):502-11. Review. PMID: 11433375
  3. Blobel CW ADAMs: key components in EGFR signalling and development. Nat Rev Mol Cell Biol. 2005 Jan;6(1):32-43. Review. PMID: 15688065