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acyl-CoA-binding protein; ACBP; diazepam-binding inhibitor; DBI; endozepine; EP (DBI)
Function:
- binds medium- & long-chain acyl-CoA esters with very high affinity
- intracellular carrier of acyl-CoA esters (putative)
- able to displace diazepam from benzodiazepine recognition site on the GABA type A receptor
- neuropeptide modulating action of GABA receptor (putative)
Structure:
- monomer
- belongs to the ACBP family
- ccontains 1 ACB domain (acyl-CoA-binding domain)
Alternative splicing: named isoforms=2
General
acyl-CoA-binding domain-containing protein (ACBP family, ACBD)
Properties
SIZE: entity length = 87 aa
MW = 10 kD
MOTIF: acyl-CoA-binding domain {2-87}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
Tyr phosphorylation site {Y29}
Database Correlations
OMIM 125950
UniProt P07108
Pfam PF00887
Entrez Gene 1622
Kegg hsa:1622
References
- UniProt :accession P07108
- OMIM :accession 125950