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acute myelomonocytic leukemia/AML-M4Eos

Fusion protein: cbf-beta with smooth muscle myosin heavy chain. Increased eosinophils in bone marrow; Most favorable prognosis of all AMLs; propensity for CNS involvement.

Properties

GENETIC-ABNORMALITY: chromosomal inversion LOCUS: human chromosome-16 P13 human chromosome-16 Q22

Database Correlations

OMIM 607785

References

  1. Knowles. Neoplastic Hematopathology, Williams & Wilkins, 1992 pg 1330
  2. Liu et al, Fusion between transcription factor CBF beta/PEB2 beta and a myosin heavy chain in acute myeloid leukemia. Science 261:1041 1993 PMID: 8351518