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AML-M5; acute monocytic leukemia
Promonocytes or monoblasts.
Pathology:
- bone marrow biopsy
- bone marrow specimen stained with hematoxylin & eosin (image [3])
- leukemic infiltration of the marrow with monoblasts (Panel A, ;
Genetics:
- juxtaposition of the interferon & c-ETS-1 proto-oncogene may be involved in the pathogenesis of monocytic leukemia
Clinical manifestations:
- fever, fatigue, dyspnea (from case report [3])
- distended abdomen, hepatosplenomegaly
- cervical lymphadenopathy
Laboratory:
- complete blood count:
- WBC may be > 100,000/uL, monocytes may be > 90%
- thrombocytopenia: platelet count may be < 40,000/uL
Complications:
- tumor lysis syndrome & disseminated intravascular coagulation with chemotherapy induction [3]
- bone marrow necrosis (image [3])
- recurrence after treatment
Management:
- chemotherapy
Interactions
disease interactions
Specific
acute monoblastic leukemia/aml-m5a
acute monocytic leukemia with differentiation/aml-m5b
General
acute myeloid leukemia (AML)
monocytic leukemia
Database Correlations
OMIM 159555
References
- Cotran et al Robbins Pathologic Basis of Disease,
W.B. Saunders Co, Philadelphia, PA 1989 pg 726
- Mihova D
Leukemia acute
AML not otherwise categorized
Acute monoblastic and acute monocytic leukemia (AML- M5)
Pathology Outlines
http://www.pathologyoutlines.com/topic/leukemiaacutemonocyticleukemia.html
- Terao T, Matsuev K.
Images in Clinical Medicine. Bone Marrow Necrosis in Acute Monoblastic Leukemia.
N Engl J Med 2021; 384:650 Feb 18
PMID: 33596359
https://www.nejm.org/doi/full/10.1056/NEJMicm2026508