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AML-M7; acute megakaryoblastic leukemia

AML with > 50% of blasts from megakaryocytic lineage Epidemiology: - ~3-5% of AML cases - adults and children Pathology: - pleomorphic undifferentiated blasts; react with antiplatelet antibodies - myelofibrosis or increased bone marrow reticulin Genetics: - implicated genes: - GFI1B, CD41, CD61

Interactions

disease interactions

General

acute myeloid leukemia (AML)

References

  1. Cotran et al Robbins Pathologic Basis of Disease, W.B. Saunders Co, Philadelphia, PA 1989 pg 726
  2. Mihova D Leukemia - Acute AML not otherwise categorized Acute megakaryoblastic leukemia (AMKL, M7) Pathology Outlines http://www.pathologyoutlines.com/topic/leukemiaM7.html