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acute eosinophilic leukemia

Epidemiology: rare Genetics: - t(8;9)(p22;p24) involving JAK2 with PCM1 are found in both chronic & acute forms of eosinophilic, lymphoblastic & myeloid leukemia - translocation links the protein kinase domain of JAK2 to PCM1 - t(5;12)(q31;p13) involving ETV6 with ACSL6 Laboratory: 1) complete blood count (CBC): marked eosinophilia 2) peripheral smear: dysplastic eosinophils 3) bone marrow biopsy: increased blasts

Interactions

disease interactions

General

acute myeloid leukemia (AML) eosinophilic leukemia

References

  1. WHO Classification Tumours of Haematopoietic and Lymphoid Tissues. IARC Press 2001; page 102.
  2. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998