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acute basophilic leukemia
Acute myeloid leukemia with primary differentiation toward basophils
Epidemiology:
- rare; < 1% of leukemias
Genetics: no consistent chromosomal abnormality identified
Microscopic Pathology:
- medium sized blasts, high nuclear/cytoplasmic ratio
- moderately basophilic cytoplasm,
- variable numbers of coarse basophilic granules
Immunophenotype:
- myeloid markers: CD13, CD33
- early hematopoietic markers: CD34, class-II HLA-DR
- CD9
- some TdT
- negative for lymphoid markers
Clinical manifestations:
- features related to bone marrow failure
- circulating blasts +/-
- organomegaly +/-
- cutaneous involvement +/-
- lytic lesions +/-
- symptoms of hyperhistaminemia +/-
Interactions
disease interactions
Related
basophil
General
acute myeloid leukemia (AML)
References
- WHO Classification Tumours of Haematopoietic and Lymphoid
Tissues. IARC Press 2001
- Khattar P, YaBE M
Leukemia acute
AML not otherwise categorized
Acute basophilic leukemia
Pathology Outlines
http://www.pathologyoutlines.com/topic/leukemiabasophil.html