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alpha-actinin-1; alpha-actinin cytoskeletal isoform; non-muscle alpha-actinin-1; F-actin cross-linking protein (ACTN1)
Function:
- F-actin cross-linking protein thought to anchor actin to a variety of intracellular structures
- ACTN1 is a bundling protein
Structure:
- homodimer; antiparallel. interacts with DDN, MYOZ2, PDLIM2, TTID & LPP
- belongs to the alpha-actinin family
- contains 1 actin-binding domain
- contains 2 CH (calponin-homology) domains
- contains 2 EF-hand domains
- contains 4 spectrin repeats
Compartment:
- cytoplasm, cytoskeleton
- cytoplasm, myofibril, sarcomere, Z-disk
- colocalizes with MYOZ2 & PPP3CA at the Z-line of heart & skeletal muscle
General
alpha-actinin (ACTN)
Properties
CONFIGURATION: dimer
SIZE: entity length = 892 aa
MW = 103 kD
COMPARTMENT: cytoplasm
MOTIF: actin-binding site
SITE: 1-247
FOR-BINDING-OF: F-actin
MOTIF: Tyr phosphorylation site {Y12}
calponin homology domain
NAME: calponin homology domain
SITE: 31-135
Thr phosphorylation site {T50}
Ser phosphorylation site {S140}
calponin homology domain
NAME: calponin homology domain
SITE: 144-247
Tyr phosphorylation site {Y193}
DDN interaction {274-733}
MOTIF: spectrin repeat {274-384}
spectrin repeat {394-499}
spectrin repeat {509-620}
spectrin repeat {630-733}
EF hand
SITE: 746-781
MOTIF: Ca+2-binding site
SITE: 759-770
EF hand
SITE: 787-822
MOTIF: Ca+2-binding site
SITE: 800-811
Database Correlations
OMIM 102575
UniProt P12814
PFAM correlations
Entrez Gene 87
Kegg hsa:87
References
- UniProt :accession P12814
- Entrez Gene :accession 87