activating protein 1 (AP1)

Activated by PKC. May associate with additional nuclear proteins.

General

DNA-binding protein redox-modulated transcription factor transcription factor complex

Properties

COMPARTMENT: cell nucleus MOTIF: DNA-binding motif SUBUNITS: proto-oncogene protein c-Fos MOTIF: DNA-binding motif SITE: 139-160 leucine zipper SITE: 165-193 FOR-BINDING-VIA: leucine zipper Thr phosphorylation site {T232} basic helix-loop-helix {CBHLH} MOTIF: basic DNA-binding motif MOTIF: cysteine residue helix-loop-helix NAME: helix-loop-helix EFFECTOR-BOUND: c-jun proto-oncogene protein BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: LZ EFFECTOR-BOUND: c-jun proto-oncogene protein BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper LEUCINES: 5 Thr phosphorylation site {T325} Thr phosphorylation site {T331} Ser phosphorylation site {S362} Ser phosphorylation site {S374} c-jun proto-oncogene protein MOTIF: Thr phosphorylation site {T2} Thr phosphorylation site {T8} Ser phosphorylation site {S58} Thr phosphorylation site {T62} Ser phosphorylation site {S63} Ser phosphorylation site {S73} Thr phosphorylation site {T89} Thr phosphorylation site {T93} Thr phosphorylation site {T239} Ser phosphorylation site {S243} hinge region basic helix-loop-helix {C-TERMINAL} MOTIF: basic DNA-binding motif MOTIF: cysteine residue {X+1} helix-loop-helix NAME: helix-loop-helix EFFECTOR-BOUND: proto-oncogene protein c-Fos BOUND-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: C-TERMINAL EFFECTOR-BOUND: proto-oncogene protein c-Fos BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper LEUCINES: 5 Ser phosphorylation site {S249} DNA-binding motif SITE: 257-276 MOTIF: cysteine residue {269} arginine residue {272} helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 280-308 FOR-BINDING-VIA: leucine zipper MOTIF: Thr phosphorylation site {T286}

Components

c-jun proto-oncogene protein; v-jun avian sarcoma virus 17 oncogene homolog; p39 (JUN) jun protein family proto-oncogene protein c-Fos; cellular oncogene protein fos; G0/G1 switch regulatory protein 7 (FOS, G0S7)