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masoprocol; nordihydroguaiaretic acid; NDGA (Actinex)

Derived from plant Larrea divaricata Tradename: Actinex. Dosage: Actinic keratosis: apply BID for about 1 month Cream 10%. Adverse effects: 1) contact sensitization (9%) 2) redness, flaking, pruritus are common Mechanism of action: 1) 5-lipoxygenase inhibitor [2] 2) antitumor activity No comparative double-blind studies with 5-fluorouracil

General

lipoxygenase inhibitor polyphenol topical agent

Properties

SIZE: MW = 302.4 G/MOL MISC-INFO: elimination route LIVER KIDNEY pregnancy-category B safety in lactation ?

Database Correlations

PUBCHEM correlations

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996 pg 1612