actin

Classification: - in vertebrates, there are 3 main groups of actin isoforms, alpha-actins, beta-actins & gamma-actins - the alpha-actins are found in muscle tissues & are a major constituent of the contractile apparatus - the beta-actins & gamma-actins coexist in most cell types as components of the cytoskeleton & as mediators of internal cell motility Function: - involved in various types of cell motility - polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix - each actin can bind to 4 others Structure: -actins are highly conserved proteins Expression: - ubiquitously expressed in all eukaryotic cells Laboratory: - actin antigen in tissue - actin antibody in serum Notes: - 10% of a typical cell's protein is actin, about 50% is in the polymeric state

Specific

actin, cytoplasmic 1; beta-actin (ACTB) actin, cytoplasmic 2; gamma-actin (ACTG1, ACTG) alpha actin F-actin protein beta-actin-like; Kappa-actin (ACTK, ACTBL2)

General

contractile protein microfilament protein

Properties

COMPARTMENT: cytoplasm MOTIF: coiled coil

References

UniProt :accession Q562R1