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pituitary adenoma/ACTH secreting

Pathology: -> often basophilic appearing adenomas Genetics: - associated with defects in AIP Clinical manifestations: see Cushing's syndrome Differential diagnosis: -> rare abdominal or chest tumor secreting ectopic CRH Management: 1) pharmaceutical agents a) ketoconazole b) metyrapone c) cabergoline d) mifepristone e) mitotane f) etomidate [1] 2) also see pituitary adenoma

Related

adrenocorticotropic hormone; corticotropin; adrenocorticotropin (ACTH) corticotropin-releasing factor; corticoliberin; CRF; corticotropin-releasing hormone (CRH) Cushing's syndrome; hypercortisolism; hyperadrenocorticism; pluriglandular syndrome ectopic ACTH syndrome

Specific

Nelson's syndrome

General

pituitary adenoma

Database Correlations

OMIM 219090

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 15, 18. American College of Physicians, Philadelphia 2009, 2018.
  2. Harrison's Online, Chapter 370, McGraw-Hill, 2002