actin, cytoplasmic 2; gamma-actin (ACTG1, ACTG)

Function: - cytoplasmic actins - role in cell motility - polymerization of globular actin (G-actin) leads to a structural filament (F-actin) - each actin can bind to 4 others Structure: belongs to the actin family Compartment: cytoplasm, cytoskeleton Pathology: - defects in ACTG1 are the cause of deafness autosomal dominant type 20

General

actin phosphoprotein

Properties

SIZE: entity length = 375 aa MW = 42 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Tyr phosphorylation site {Y169} Tyr phosphorylation site {Y198} Tyr phosphorylation site {Y294} Thr phosphorylation site {T318}

Database Correlations

OMIM correlations MORBIDMAP 102560 UniProt P63261 Pfam PF00022 Entrez Gene 71 Kegg hsa:71; -.

References

UniProt :accession P63261