Search
acrosin ([contains: acrosin light chain; Acrosin heavy chain], ACR, ACRS)
Function:
- major protease of mammalian spermatozoa
- serine protease of trypsin-like cleavage specificity
- synthesized in a zymogen form, proacrosin & stored in the acrosome
- preferential cleavage: Arg-|-Xaa, Lys-|-Xaa
Structure:
- heavy chain (catalytic) & a light chain linked by two disulfide bonds
- belongs to the peptidase S1 family
- contains 1 peptidase S1 domain
Laboratory:
- acrosin in spermatozoa
General
serine protease trypsin family
Properties
SIZE: entity length = 421 aa
MW = 46 kD
MOTIF: signal sequence {1-19}
N-glycosylation site {N22}
cysteine residue {C25}
MODIFICATION: cysteine residue {C-INTERCHAIN}
cysteine residue {C29}
MODIFICATION: cysteine residue {C-INTERCHAIN}
S1 domain {43-290}
MOTIF: cysteine residue {C73}
MODIFICATION: cysteine residue {C89}
histidine residue {H88}
cysteine residue {C89}
MODIFICATION: cysteine residue {C73}
aspartate residue {D142}
cysteine residue {C177}
MODIFICATION: cysteine residue {C246}
cysteine residue {C209}
MODIFICATION: cysteine residue {C225}
N-glycosylation site {N210}
cysteine residue {C225}
MODIFICATION: cysteine residue {C209}
cysteine residue {C236}
MODIFICATION: cysteine residue {C266}
serine residue {S240}
cysteine residue {C246}
MODIFICATION: cysteine residue {C177}
cysteine residue {C266}
MODIFICATION: cysteine residue {C236}
Database Correlations
OMIM 102480
UniProt P10323
Entrez Gene 49
Kegg hsa:49;
ENZYME 3.4.21.10
References
UniProt :accession P10323