testicular acid phosphatase (ACPT)

Function: - dephosphorylates receptor tyrosine-protein kinase erbB-4 & inhibits the ligand-induced proteolytic cleavage Structure: - homodimer - belongs to the histidine acid phosphatase family Compartment: membrane Alternative splicing: named isoforms=3 Expression: - expressed mainly in the testis - also expressed in brain, enriched at the post-synaptic sites - expressed at lower levels in the trachea, prostate, bone marrow, spinal cord, colon, fetal brain, heart, thymus, fetal liver, spleen, leukocytes, ovary, small intestine, pancreas, skeletal muscle - isoform 3 is expressed in testis, trachea, prostate, bone marrow - up-regulated by mibolerone (a synthetic androgen) & dihydrotestosterone (DHT) - down-regulated by estrogen & progestin Pathology: - expression is significantly lower in testicular cancer than in normal testicular tissues

Properties

SIZE: MW = 46 kD entity length = 426 aa MOTIF: signal sequence {1-26} histidine residue {H41} cysteine residue {C159} MODIFICATION: cysteine residue {C378} N-glycosylation site {N191} cysteine residue {C214} MODIFICATION: cysteine residue {C312} N-glycosylation site {N269} aspartate residue {D289} cysteine residue {C312} MODIFICATION: cysteine residue {C214} N-glycosylation site {N330} N-glycosylation site {N339} cysteine residue {C353} MODIFICATION: cysteine residue {C357} cysteine residue {C357} MODIFICATION: cysteine residue {C353} cysteine residue {C378} MODIFICATION: cysteine residue {C159} transmembrane domain {394-414}

Database Correlations

OMIM 606362 UniProt Q9BZG2 Pfam PF00328 ENZYME 3.1.3.2

References

UniProt :accession Q9BZG2