2-amino-3-carboxymuconate-6-semialdehyde decarboxylase (ACMSD)

Function: 1) biosynthesis of NAD from tryptophan (kynurenine pathway) - compare with picolinate carboxylase 2) converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS) 2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate (--> 2-aminomuconate semialdehyde + CO₂ Structure: - belongs to the ACMSD family Alternative splicing: named isoforms=2 Pathology: - ACMS can be converted non-enzymatically to quinolate, a potent endogenous excitotoxin of neuronal cells implicated in pathogenesis of neurodegenerative disorders - AMCSD convers ACMS to AMS, a benign catabolite

Properties

SIZE: MW = 38 kD entity length = 336 aa MOTIF: active site

Database Correlations

OMIM 608889 UniProt Q8TDX5 Pfam PF04909 ENZYME 4.1.1.45

References

UniProt :accession Q8TDX5