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acid-base balance

Both the lungs (through expiration of CO2) & the kidneys regulate acid base balance Normal daily endogenous acid production (excluding CO2) is approximately: 50-70 mmol/24 hours or 1 mmol/kg/day. In patients with acute renal failure, plasma [HC03-] decreases by approximately 1-2 meq/L/day. Normal acid-base values: pCO2 = 38-42 mm Hg [HCO3-] = 24-28 mmol/L [H+] = 40 mmol/L

Related

acid-base disorder Henderson-Hasselbalch equation

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, 14, 18. American College of Physicians, Philadelphia 1998, 2006, 2018.
  2. Clinical Diagnosis & Management by Laboratory Methods, 19th edition, J.B. Henry (ed), W.B. Saunders Co., Philadelphia, PA. 1996, pg 150, 152
  3. Adrogue HJ, Madias NE. Secondary responses to altered acid-base status: the rules of engagement. J Am Soc Nephrol. 2010 Jun;21(6):920-3. PMID: 20431042
  4. Seifter JL, Chang HY. Disorders of Acid-Base Balance: New Perspectives. Kidney Dis (Basel). 2017 Jan;2(4):170-186. Review. PMID: 28232934 Free PMC Article