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acetylcholine (nicotinic) receptor blocking Ab in serum
Indications:
- evaluation of myasthenia gravis (MG)
Normal range:
- < 20% inhibition of I=125-alpha-bungarotoxin
Principle:
- 3rd line diagnostic test for myasthenia gravis (MG)
- measures inhibition of I-125-alpha-bungarotoxin to nicotinic receptor substrate
Clinical significance:
- positivity:
a) 61% in generalized MG
b) 25% in ocular MG
n) 35% of MG in remission
Method:
- Radioimmunoassay (RIA)
Specimen:
1) serum
2) store refrigerated or frozen without preservative
3) do NOT use plasma
4) stable at -20 degrees C Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed., W.B. Saunders, 1995
Related
myasthenia gravis
nicotinic receptor (nicotinic acetylcholine receptor, nAChR)
General
acetylcholine (nicotinic) receptor modulating Ab in serum