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acetohexamide (Dymelor)
Tradename: Dymelor.
Dosage: start with 250 mg PO QD, max 1500 mg/day divided BID
Tabs: 250 & 500 mg. Active metabolite: hydroxyhexamide.
Adverse effects:
1) transient leukopenia
2) thrombocytopenia
3) hemolytic anemia
4) pancytopenia
5) gastrointestinal disturbances
6) headache
7) tinnitus
8) photosensitivity
9) allergic skin reactions
10) intolerance to alcohol
11) hypoglycemia
12) hepatic dysfunction [2]
Drug interactions:
-> agents that increase risk of hypoglycemia
-> sulfonamides, beta-blockers, salicylates, clofibrate, phenylbutazone, probenecid, dicumorol, warfarin, chloramphenicol, MAO inhibitors, alcohol [2]
Laboratory:
1) specimen: serum
2) methods: HPLC, GLC, color
3) interferences:
a) color: hemolysis, primary & secondary amines
b) GLC: plasma lipids
Mechanism of action:
1) sulfonylurea
2) small diuretic effect
Interactions
drug interactions
drug adverse effects (more general classes)
monitor with sulfonylureas
General
sulfonylurea
Properties
MISC-INFO: elimination route LIVER
KIDNEY
1/2life 1.3 HOURS
6.0 HOURS
therapeutic-range 20-70 UG/ML
protein-binding 96%
elimination by peritoneal dialysis -
Database Correlations
PUBCHEM cid=1989
References
- The Pharmacological Basis of Therapeutics, 9th ed.
Gilman et al, eds. Permagon Press/McGraw Hill, 1996
- Clinical Guide to Laboratory Tests, 3rd ed. Teitz ed.,
W.B. Saunders, 1995