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acetaminophen/propoxyphene (Darvocet, Wygesic)

DEA-controlled substance: class 4. Propoxyphene banned by FDA Feb 2009 Indications: management of mild to moderate pain Contraindications: pregnancy-category C safety in lactation ? Dosage: N-50: (50 mg propoxyphene + 325 mg acetaminophen): - 2 tabs PO every 4 hours. N-100: (100 mg propoxyphene + 650 mg acetaminophen)* A-500: (100 mg propoxyphene + 500 mg acetaminophen)* - 1 tab PO every 4 hours. Wygesic: (65 mg propoxyphene + 650 mg acetaminophen) - 1 tab PO every 4 hours. * 1 A-500 tablet is NOT equal to 5 N-100 tablets! [3] Pharmacokinetics: elimination: liver Adverse effects: - not common (1-10%) - dizziness, lightheadedness, headache, weakness, sedation, paradoxical excitement & insomnia, rash, GI upset, tolerance, physical & psychologic dependence

Interactions

drug interactions drug adverse effects of opiates

General

narcotic combination

Database Correlations

PUBCHEM cid=123857

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996
  2. Kaiser Permanente Northern California Regional Drug Formulary, 1998
  3. Prescriber's Letter 10(11):64 2003
  4. Darvocet Label http://www.xanodyne.com/pdf/Darvocet_A500.pdf

Components

acetaminophen (Tylenol, Paracematol, Panadol, Tempra, Datril, APAP, non-Aspirin) propoxyphene (Darvon, Dolene, Proxagesic, Novopropoxyn)