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amiloride-sensitive cation channel 3 (acid-sensing ion channel 3, ASIC3, hASIC3, testis sodium channel 1, hTNaC1, ACCN3, ASIC3, SLNAC1, TNAC1)
Function:
1) cation channel with high affinity for Na+
2) gated by extracellular H+
3) inhibited by amiloride
4) generates a biphasic current
- fast inactivating & slow sustained phase
5) in sensory neurons, mediates pain induced by acidosis from ischemia or inflammation (putative)
6) involved in hyperalgesia (putative)
7) role in mechanoreception (putative)
8) phosphorylated by PKA, PKC
9) potentiated by FMRFamide-related neuropeptides
10) sensitized & potentiated by NPSF
11) regulated by lactate & Ca+2
12) inhibited by anti-inflammatory drugs, like salicylic acid
13) sensitized & potentiated by NPFF
14) interacts with STOM & DLG4
15) interacts with LIN7B, MAGI1/BAIAP1, GOPC, ACCN1
16) heteromeric channel assembly seems to modulate channel properties
Structure:
- the PDZ domain-binding motif is involved in interaction with LIN7A, GOPC & MAGI1
- belongs to the amiloride-sensitive Na+ channel family
Compartment:
- cell membrane, cytoplasm
- cell surface expression stabilized by interaction with LIN7B
- cytoplasmic retention stabilized by interaction with DLG4
Alternative splicing: named isoforms=4
Expression:
- expressed by sensory neurons
- strongly expressed in brain, spinal cord, lung, lymph nodes, kidney, pituitary, heart, testis
- expressed in fetal tissues
- expression increases in lung & kidney adult tissues
Miscellaneous:
- potentiated by FMRFamide-related neuropeptides sensitized & potentiated by NPSF
- regulated by lactate & Ca+2
- inhibited by anti-inflammatory drugs, including salicylic acid (putative)
- sensitized & potentiated by NPFF
General
amiloride-sensitive cation channel
transmembrane 2 protein
Properties
SIZE: MW = 59 kD
entity length = 531 aa
COMPARTMENT: cytoplasm
MOTIF: cytoplasmic domain {1-43}
transmembrane domain {44-61}
exoplasmic loop {62-441}
MOTIF: N-glycosylation site {N175}
N-glycosylation site {N398}
transmembrane domain {442-460}
cytoplasmic domain {461-531}
MOTIF: Ser phosphorylation site {S521}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 528-531
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 611741
UniProt Q9UHC3
Pfam PF00858
Entrez Gene 9311
Kegg hsa:9311
References
UniProt :accession Q9UHC3