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amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive brain Na+ channel; amiloride-sensitive cation channel neuronal 1; acid-sensing ion channel 2; ASIC2; brain Na+ channel 1; BNaC1; BNC1; mammalian degenerin homolog (ACCN1, ACCN, BNAC1 MDEG)
Function:
- cation channel with high affinity for Na+
- gated by extracellular protons
- inhibited by the diuretic amiloride
- also permeable for Li+ & K+
- generates a biphasic current with a fast inactivating & a slow sustained phase
- heteromeric channel assembly seems to modulate activity
- homotetramer or heterotetramer with other ASIC proteins (probable)
- interacts with STOM (putative)
- interacts with PRKCABP & ACCN3
Structure:
- belongs to the amiloride-sensitive Na+ channel family
Compartment:
- cell membrane; multi-pass membrane protein
- localized at the plasma membrane of neurons, in the soma & punctated peripheral processes (putative)
Alternative splicing: named isoforms=2
Expression:
- brain & spinal cord
- isoform 1 is also detected in testis, liver, colon & ovary
Notes:
- inhibited by anti-inflammatory agents including salicylic acid (putative)
- regulated by Zn+2
General
amiloride-sensitive cation channel
human longevity protein
transmembrane 2 protein
Properties
SIZE: entity length = 512 aa
MW = 58 kD
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-37}
transmembrane domain {38-58}
exoplasmic loop {59-427}
MOTIF: cysteine residue {C92}
MODIFICATION: cysteine residue {C193}
cysteine residue {C171}
MODIFICATION: cysteine residue {C178}
cysteine residue {C178}
MODIFICATION: cysteine residue {C171}
cysteine residue {C193}
MODIFICATION: cysteine residue {C92}
cysteine residue {C289}
MODIFICATION: cysteine residue {C364}
cysteine residue {C307}
MODIFICATION: cysteine residue {C360}
cysteine residue {C311}
MODIFICATION: cysteine residue {C358}
cysteine residue {C320}
MODIFICATION: cysteine residue {C342}
cysteine residue {C322}
MODIFICATION: cysteine residue {C334}
cysteine residue {C334}
MODIFICATION: cysteine residue {C322}
cysteine residue {C342}
MODIFICATION: cysteine residue {C320}
cysteine residue {C358}
MODIFICATION: cysteine residue {C311}
cysteine residue {C360}
MODIFICATION: cysteine residue {C307}
cysteine residue {C364}
MODIFICATION: cysteine residue {C289}
N-glycosylation site {N365}
N-glycosylation site {N392}
transmembrane domain {428-448}
cytoplasmic domain {449-512}
Database Correlations
OMIM 601784
UniProt Q16515
Pfam PF00858
Entrez Gene 40
Kegg hsa:40
References
UniProt :accession Q16515