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acetyl-CoA carboxylase 1 (ACC-alpha, [includes: biotin carboxylase], ACACA, ACAC, ACC1, ACCA)

Function: - catalyzes rate-limiting reaction in biogenesis of long-chain fatty acids - carries out 3 functions: a) biotin carboxyl carrier protein b) biotin carboxylase c) carboxyltransferase - interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation & inhibits lipid synthesis - long-chain fatty acid biosynthesis; 1st (rate-limiting) step - phosphorylation on Ser-1263 is required for interaction with BRCA1 ATP + acetyl-CoA + HCO3- ADP + phosphate + malonyl-CoA ATP + biotin-carboxyl-carrier protein + CO2 ADP + phosphate + carboxybiotin-carboxyl-carrier protein Cofactor: - biotin - binds 2 Mn+2 per subunit Structure: - contains 1 ATP-grasp domain - contains 1 biotin carboxylation domain - contains 1 biotinyl-binding domain - contains 1 carboxyltransferase domain Compartment: cytoplasm Alternative promoter usage: named isoforms=4 Expression: - expressed in brain, placental, skeletal muscle, renal, pancreatic & adipose tissues - expressed at low level in pulmonary tissue - not detected in the liver

General

acetyl CoA carboxylase phosphoprotein

Properties

SIZE: entity length = 2346 aa MW = 266 kD COMPARTMENT: cytoplasm MOTIF: Ser phosphorylation site {S23} Ser phosphorylation site {S25} Ser phosphorylation site {S29} Ser phosphorylation site {S48} Ser phosphorylation site {S50} Ser phosphorylation site {S53} Ser phosphorylation site {S56} Thr phosphorylation site {T58} Ser phosphorylation site {S60} Ser phosphorylation site {S78} Ser phosphorylation site {S80} Biotin carboxylation {117-618} MOTIF: ATP-grasp domain SITE: 275-466 ATP-binding site NAME: ATP-binding site SITE: 315-320 manganese [Mn]-binding site SITE: 424-424 manganese [Mn]-binding site SITE: 437-437 manganese [Mn]-binding site SITE: 439-439 arginine residue {R441} binding site SITE: 752-818 FOR-BINDING-OF: BIOTINYL MOTIF: binding site SITE: 786-786 FOR-BINDING-OF: Biotin (covalent) Thr phosphorylation site {T1042} Ser phosphorylation site {S1201} Ser phosphorylation site {S1263} Carboxyltransferase {1698-2194} MOTIF: binding site SITE: 1823-1823 FOR-BINDING-OF: Coenzyme A Ser phosphorylation site {S2099} Tyr phosphorylation site {Y2108} binding site SITE: 2127-2127 FOR-BINDING-OF: Coenzyme A binding site SITE: 2129-2129 FOR-BINDING-OF: Coenzyme A

Database Correlations

OMIM 200350 UniProt Q13085 PFAM correlations Entrez Gene 31 Kegg hsa:31; ENZYME correlations

References

  1. UniProt :accession Q13085
  2. Wikipedia, acetyl-CoA carboxylase entry http://en.wikipedia.org/wiki/acetyl-CoA_carboxylase