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ATP-dependent RNA helicase DDX41; DEAD box protein 41; DEAD box protein abstrakt homolog (DDX41, ABS)
Function:
- probable ATP-dependent RNA helicase
- required during post-transcriptional gene expression
- may be involved in pre-mRNA splicing
- ATP + H2O = ADP + phosphate
- identified in the spliceosome C complex
Structure:
- belongs to the DEAD box helicase family, DDX41 subfamily
- contains 1 CCHC-type Zn+2 finger
- contains 1 helicase ATP-binding domain
- contains 1 helicase C-terminal domain
Compartment: nucleus (putative)
General
DEAD box ATP-dependent helicase
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 622 aa
MW = 70 kD
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S21}
Ser phosphorylation site {S23}
Q motif {181-209}
helicase
NAME: helicase
SITE: 212-396
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 225-232
DEAD/H box
NAME: DEAD/H box
SITE: 344-347
Helicase C-terminal {407-567}
Zn finger C2HC-type
SITE: 580-597
EFFECTOR-BOUND: Zn+2
Database Correlations
OMIM 608170
UniProt Q9UJV9
PFAM correlations
Entrez Gene 51428
Kegg hsa:51428
ENZYME 3.6.4.13
References
UniProt :accession Q9UJV9
Component-of
spliceosome C complex