ABri amyloid

Derived from integral membrane protein 2B (ITM2B) Pathology: - point mutation at stop codon results in a 277 aa residue ITM2B protein (normal 266 aa), of which release of the 34 C-terminal amino acids generates amyloid - this mutation is associated with familial British dementia - deposits of ABri result in cerebral amyloid angiopathy - soluble form (sABri) found in plasma & in blood vessels & parenchyma of other organs (see familial British dementia)

Properties

SIZE: entity length = 34 aa