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active breakpoint cluster region-related protein (ABR)
Function:
1) GTPase-activating protein for RAC & CDC42
2) promotes exchange of RAC or CDC42-bound GDP by GTP thus activating them
Structure:
- contains 1 C2 domain
- contains 1 DH domain (DBL-homology)
- contains 1 PH domain
- contains 1 Rho-GAP domain
Alternative splicing: named isoforms=2
Expression: expressed in brain >> heart, lung, muscle
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 98 kD
entity length = 859 aa
MOTIF: Dbl homology domain {91-284}
PH domain {301-459}
C2 domain {463-595}
MOTIF: binding site
FOR-BINDING-OF: phospholipid
Ca+2-binding site
rho-GAP domain
NAME: rho-GAP domain
SITE: 647-845
Database Correlations
OMIM 600365
UniProt Q12979
PFAM correlations
References
UniProt :accession Q12979