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ABO blood group locus

Structure: - blood group ABO involves three carbohydrate antigens: A,B, & H - A, B, & AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-galNAc) or to the B antigen (by addition of UDP-gal), whereas O individuals lack such activity Pathology: - ABO blood type: AB (1.23), B (1.15), & A (1.08), (risk relative to those with type O blood) [2]

General

blood group locus

Properties

LOCUS: human chromosome-9 Q34 COMPARTMENT: cell nucleus CELL: unspecified cell type ORGANISM: Homo sapiens

Database Correlations

OMIM 110300 Entrez Gene 28

References

  1. OMIM :accession 110300
  2. He M, Wolpin B, Rexrode K et al ABO Blood Group and Risk of Coronary Heart Disease in Two Prospective Cohort Studies ATVBAHA.112.248757, August 14, 2012 PMID: 22895671 http://atvb.ahajournals.org/content/early/2012/08/14/ATVBAHA.112.248757.abstract