Abl interactor 2; Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 (ABI2, ARGBPIA)

Function: 1) regulation of cell growth & transformation 2) interacts with nonreceptor tyrosine kinases ABL1 &/or ABL2 3) cytoskeletal reorganization 4) regulates ABL1-mediated phosphorylation of MENA 5) interacts with ABL1 & ABL2 6) substrate for ABL1 7) component of the WAVE complex 8) interacts with the Arp2/3 complex Structure: - belongs to the ABI family - contains 1 SH3 domain - contains 1 t-SNARE coiled-coil homology domain Compartment: - cytoplasm - isoform 1 localized to protruding lamellipodia & filopodia tips Alternative splicing: named isoforms=4

Properties

SIZE: entity length = 513 aa MW = 56 kD COMPARTMENT: cytoplasm MOTIF: SNARE motif {45-107} proline-rich region SITE: 172-423 MOTIF: proline residue (SEVERAL) Tyr phosphorylation site {Y213} Ser phosphorylation site {S227} src homology 3 [SH3] domain SITE: 451-510 MOTIF: Tyr phosphorylation site {Y462}

Database Correlations

OMIM 606442 UniProt Q9NYB9 PFAM correlations Entrez Gene 10152 Kegg hsa:10152

References

UniProt :accession Q9NYB9