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ATP-binding cassette sub-family G member 1; ATP-binding cassette transporter 8; White protein homolog (ABCG1 ABC8, WHT1)

Function: - transporter involved in macrophage lipid homeostasis - active component of the macrophage lipid export complex - role in intracellular lipid transport processes - role in cellular lipid homeostasis may not be limited to macrophages - may form heterodimers with several heterologous partners of the ABCG subfamily Structure: - belongs to the ABC transporter family, ABCG (White) subfamily - contains 1 ABC transporter domain Compartment: - endoplasmic reticulum membrane - Golgi membrane - predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) & Golgi membranes Alternative splicing: named isoforms=8 Additional isoforms seem to exist Expression: - expressed in several tissues - strongly induced in monocyte-derived macrophages during cholesterol influx - conversely, mRNA & protein expression are suppressed by lipid efflux - induction is mediated by the LXR/RXR pathway - not induced by bacterial lipopolysaccharides (LPS) - repressed by ZNF202 - highly induced in lipid-laden macrophages. Pathology: - overexpressed in macrophages from patients with Tangier disease compared to control macrophages - expressed in foamy macrophages within atherosclerotic plaques - role in cholesterol metabolism of macrophages in vitro & in atherosclerotic plaques

Related

ATP-binding cassette 8 (ABC8) gene

General

ATP-binding cassette sub-family G (ABC transporter-G, ABG) transmembrane 6 protein

Properties

SIZE: entity length = 678 aa MW = 76 kD COMPARTMENT: golgi endoplasmic reticulum MOTIF: cytoplasmic domain {1-426} MOTIF: ABC transporter {77-317} ATP-binding site NAME: ATP-binding site SITE: 118-125 transmembrane domain {427-445} exoplasmic loop {446-456} transmembrane domain {457-477} cytoplasmic loop {478-506} transmembrane domain {507-525} exoplasmic loop {526-533} transmembrane domain {534-555} cytoplasmic loop {556-567} transmembrane domain {568-586} exoplasmic loop {587-649} transmembrane domain {650-669} cytoplasmic domain {670-678}

Database Correlations

OMIM 603076 UniProt P45844 PFAM correlations Entrez Gene 9619 Kegg hsa:9619

References

  1. UniProt :accession P45844
  2. Laffitte BA, Repa JJ, Joseph SB, Wilpitz DC, Kast HR, Mangelsdorf DJ, Tontonoz P. LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes. Proc Natl Acad Sci U S A. 2001 Jan 16;98(2):507-12. Epub 2001 Jan 9. PMID: 11149950